9/27/2023 0 Comments Download devil geneAdult Tasmanian devil infected with devil facial tumor disease. The etiologic agents of CTVT, the bivalve cancers, and DFTD are the transplants (allografts) of the neoplastic cells themselves, but the etiologic agent is unknown for the hamster tumor.Ī. Four examples of transmissible cancers are now known: 1) canine transmissible venereal tumor (CTVT) in dogs, 2) a tumor in a laboratory population of Syrian hamsters that is no longer cultured, 3) infectious neoplasias in at least four species of bivalve mollusks, and 4) two independently derived transmissible cancers (devil facial tumor disease ) in Tasmanian devils ( Fig 1A and 1B). However, transmissible cancers have been detected in vertebrate and invertebrate animals, sometimes with devastating effects. Fortunately, aside from a few rare cases of cancer transmission in immune-suppressed organ transplant recipients or a small number of transmission events from mother to fetus, cancers are not spread from human to human. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist.Ĭancer poses one of the greatest human health threats of our time. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.įunding: This work was funded by NIH Grant R01-GM126563 as part of the joint NIH-NSF-USDA Ecology and Evolution of Infectious Diseases program. Spindler, University of Michigan Medical School, UNITED STATESĬopyright: © 2018 Storfer et al. (2018) The devil is in the details: Genomics of transmissible cancers in Tasmanian devils. Citation: Storfer A, Hohenlohe PA, Margres MJ, Patton A, Fraik AK, Lawrance M, et al.
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